Trueperella pyogenes, virulence factors

Fig. 1:8. Virulence factors in Trueperella pyogenes. CbpA (collagen binding protein A), Fbp (fibrinogen binding protein) and Fnbp (fibronectin binding protein) are proteins that allow the bacterium to attach to the host cell. NanH (neuraminidase H) and NanP (neuraminidase P) are neuraminidases (= sialidases) that cleave terminal sialic acid residues from macromolecules on the surface of the host cell and then expose receptors for the binding proteins. The fimbriae increase the adhesion of the bacterium. PLO (pyolysin) is an important pathogenicity factor, which forms pores in the membrane of the host cell, which causes the cells to lyse and the contents can be degraded by DNase and proteases.

The illustration has been adapted from Figure 2 in reference no. 148.

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