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Swedish University of Agricultural Sciences

Veterinary bacteriology: information about important bacteria
Veterinary bacteriology


Species/Subspecies: Mannheimia haemolytica
Category: Causes hemolysis
Etymology: Genus name: named after the German microbiologist Walter Mannheim.
Species epithet: hemolysing.
Significance:  [Very important]   
Old Species Name(s):Pasteurella haemolytica, biotype A
Taxonomy:
Phylum
Proteobacteria
Class
Gammaproteobacteria
Order
Pasteurellales
Family
Pasteurellaceae 
Genus
Mannheimia
Type Strain: J.A. Watt 1266A&B = ATCC 33396 = CCUG 408 and 12392 = NCTC 9380.
Macromorphology (smell):
     
     
Medium sized greyish colonies (2-3 mm in diameter). Give a weak hemolysis on horse blood agar, which is easier to observe if the colonies are removed. The hemolysis is easier to observe on bovine blood agar.
Micromorphology: Nonmotile small rod
Gram +/Gram -:
     
G-
Metabolism: Facultatively anaerobic
Catalase/Oxidase:+/+
Other Enzymes: Tryptophanase -, ornithine decarboxylase -, urease -.
Biochemical Tests: Citrate -, hydrogen sulphide (H2S) -, methyl red -, Voges-Proskauer -.
Fermentation of carbohydrates:
D-glucoselactosemaltoseL-rhamnosesucrose
+v+-+
L-arabinosecellobioseD-mannitolsalicintrehalose
-?+?-
glycerolinulinraffinoseD-sorbitolstarch
v-++?
Other carbohydrates: Adonitol -, dextrin +, D-fructose +, D-fucose -, D-galactose +, D-glycogen -, mannose -, D-melezitose -, D-melibiose -, D-ribose +, L-sorbose -, xylitol -, D-xylose +.
Spec. Char.:
Special Media:
Mannheimia haemolytica  
Disease:
HostsDiseaseClinical picture
SheepEnzootic pneumonia, septicaemia, mastitisPneumonia often secondary infection after virus or Mycoplasma. Septicaemia mostly in young lambs (<3 months), severe necrotic mastitis in ewes.
CattlePneumonia (Shipping fever, Mannheimios)Severe bronchopneumonia, fever, anorexia, serous nasal discharge and pleurisy. Affect mostly young cattle.
Virulence Factors: Adhesines (two membrane proteins OmpA and Lpp1), capsule, endotoxin (toxic for bovine endothelial cells) and leukotoxin (pore-forming cytolysin), which has a potent effect on neutrophiles of ruminants that results in cell death.
Genome Sequence:
Acc-noStrainSize (bp)Genome
CP005972.1 D153 2 681 844 1c + 0 

16S rRNA Seq.:
Acc-noStrainNumber of NTOperon
AF060699 NCTC 9380T 1 504 

Taxonomy/phylogeny:
 
Six 17 have been described within genus Mannheimia. The relationship between members within the closely related genera Actinobacillus, Haemophilus and Pasteurella is very uncertain since none of these genera forms monophyletic clusters.
Reference(s): No. 108
Updated:2021-09-16

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